Suppose that a disease is inherited via a dominant mode of inheritance and that

Question

Suppose that a disease is inherited via a dominant mode of inheritance and that one of two parents is affected with the disease whereas one not. The implications of this mode of inheritance are that the probability is 1/2 + DGC/DGC + 5000 = that any particular offspring will get the disease. What is the probability that male sibling is affected and female sibling is not affected? (b)Suppose that a disease is inherited via an autosomal recessive mode of inheritance. The implications of this mode of inheritance are that the children in a family each have a probability of 0.25 + DGC/DGC + 4000 = of inheriting the disease. What is DGC 4000 the probability that male sibling is affected and female sibling is not affected?

Explanation / Answer

2.1)

a) Given the probability of affecting of any sibling = Probability of male sibling getting affected*Probability of female getting affected =0.505964*0.494036 = 0.249964

b)Probability of getting affected =0.257444

Probability of only male being getting affected =0.257444(1-0.257444) = 0.191167

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