Problem: A patient has the following volumes of distribution: deuterium oxide: 4

Question

Problem:

A patient has the following volumes of distribution:

         deuterium oxide: 42 liters            

inulin: 13 liters                           

Evans blue: 2.8 liters

Her plasma shows a freezing point depression of 0.55 degrees C. For an ideal solution, a 1 OsM solution depresses the freezing point 1.86 degrees C.

1. What is the osmolarity of her body fluids? --> 0.295

2. How much solute (osmoles) exists in each of the above compartments?

Using the data above as the initial conditions in each case, determine the effects of the following procedures on the water and solute in the ECF and ICF after equilibrium has occurred. You should be able to give the numerical values for volume and osmolarity of the ECF and ICF. Briefly explain your rationale for solving each problem. (Treat each solution below as a separate problem; do not make them additive.)

Use #2 as a starting chart for the rest of the problems. Go back to #2 as a start chart for #3-8 (each question is an independent scenario; do not make them additive).

3. Patient ingests 1 L of water, which is absorbed totally from the digestive tract.

1. Osmolarity of body fluids --> 0.295

2.

Total

ECF

ICF

Plasma

Vol L

Sol osmol

mOsM

3.

           

Total

ECF

ICF

Vol L

Sol osmol

mOsM

Explanation:

                                                                                               

Total

ECF

ICF

Plasma

Vol L

Sol osmol

mOsM

Explanation / Answer

dueterium oxide=total body water, inulin=ECF, evans blue is plasma volume, ICF=total volume-ECF

osmolarity=0.295, osmolarity=osmoles of solute/volume, mOsM -osmoles

2.

3. Water when absorbed from the digestive tract, is distributed proportionately across all the compartments. it enters the vascular system and interstitial cells and gets transported to each cell. There is no redistribution of any non-penetrating solutes i.e, no osmotic gradient is created as water does not have any solutes, so ECF does not change as there is no change in osmolarity.

Sol

osmol

ECF ICF Plasma Total Vol L 42 13 29 2.8 Sol osmol 0.295 0.295 0.295 0.295 mOsM 12.39 3.835 8.555 0.826

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