Question 11 2 pts The critical concentration (Cc) for microfilament in test tube

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Question 11 2 pts The critical concentration (Cc) for microfilament in test tube is around 0.2 uM. The cellular concentration of actin is above 20 uM, far greater than Cc of microfilament. F-actin elongation is not prevalent inside of living cells. Which of the following can explain this discrepancy? Most of Actin monomers are not available for polymerization in living cells. In living cells, treadmilling effect largely limits microfilament growth At a concentration above Cc, elongation reaction is not favorable In living cells, most of Actin is loaded with ADP

Explanation / Answer

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Answer 1: Choice 2 (According to the treadmilling effect of actin filaments, one of the ends of the actin filaments keep on growing whereas the other end is gradually degraded by enzymatic digestion. Thus, the total non-soluble actin content is never reached above a threshold and hence the discrepency is eliminated with respect to the critical concentrations and actual concentration)

Answer 2: Choices 1, 2 and 3 (Arp2/3 does not bear homology with actin but it is structurally bound to actin while undergoing elongation. In this way, this complex forms the structural unit in a cell which prevents treadmilling effect of the actin and thus stabilizes the cytoskeleton and enhances motility)

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