Dominant negative mutations produce proteins that antagonize the activity of wil

Question

Dominant negative mutations produce proteins that antagonize the activity of wild type proteins when the mutant protein and wild protein are coexpressed. Which of the following mutations would be considered a dominant negative mutation for a receptor tyrosine kinase (RTK)? a mutation which encodes a stop codon within the first few amino acids of the protein-coding sequence for an RTK O a mutation which eliminates expression of the extracellular domain of an RTK, so that it cannot dimerize B a mutation which eliminates expression of the intracellular domain of an RTK without affecting its ability to C dimenze D All of the above could produce dominant negative mutations

Explanation / Answer

Correct: option C is the correct answer because a dominant negative mutation induces the formation of a protein with dimers and multimers. An example of dominant negative mutation is the formation of homodimers by certain receptors to initiate a downstream signaling cascade when they are activated by the binding of ligands.

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