MHO Molecular Model: Muts, a DNA Mismatch Repair Protein of E.coll 15 of 28 Muts

Question

MHO Molecular Model: Muts, a DNA Mismatch Repair Protein of E.coll 15 of 28 Muts In order for Muts to recognize a base-pair mismatch, specific Muts amino acid residuss must Interact with the mismatiched base of ONA PoR Guanine Thymine Which of the following is not a specific Interaction between Muts and mismatched G-T bases? mismatched bases DNA Asp35 forms a hydrogen bond with the mismatched guanine base Asp35 forms a hydrogen bond with the mismatched thymine base Phe36 stacks with the mismatched thymine base 0u38 foms hydrogen bonds with the mismatched thymine bese Submi eest Answer Provide Feedback

Explanation / Answer

Three major interactions are found to be occurring between the DNA and the protein that repair the mismatches on DNA. The aminoacid Glu38 is found to be forming hydrogen bond with guanine10 and thymine 22 of the mismatch.

Asp35 is known to form a hydrogen bond with guanine 9 of the mismatch. Phe36 is found to be binding with T22 mismatch.

So, the interaction that is not a specific one (between MutS and mismatched G-T bases) is Asp35 forming hydrogen bond with thymine base.

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