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Development of an effective vaccine against HIV has proven difficult. Even thoug

ID: 3150593 • Letter: D

Question

Development of an effective vaccine against HIV has proven difficult. Even though the immune systems of infected individuals produces antibodies that neautralize circulating viris, the disease destroys the CD4 T cells producing those antibodies. Balaz et al. (2011) investigated a novel HIV treatment that bypasses the immune system. They used a special strain of :humanized" mice that carry human CD4 T cells, which are susceptible to HIV. treatment mice recievd human antibody-producing genes, which wer injected into leg muscle using a marmless virus. Control mice were injected with a reporter gene instead (luciferase). all mice were then injected with high doses of HIV. the data below record the percentage of healthy CD4 T cells remaining in the mice five weeks later. a High value indicates that many CD4 T cells remain, and hence that HIV has been neautralized, whearas a low value indicates that the mouse has succumbed to the disease.

Antibody treatment mice: 94, 96, 92, 88, 84, 81, 76, 54

Control teatment mice: 20, 15, 11, 7, 3, 0

B) what are the most-plausible values for the means of each of the two treatments?

Explanation / Answer

B) what are the most-plausible values for the means of each of the two treatments?

It is their sample means.

For ANTIBODY TREATMENT:

Getting the mean, X,  
  
X = Sum(x) / n  
Summing the items, Sum(x) =    665
As n =    8
Thus,  
X =    83.125 [ANSWER]

For the CONTROL TREATMENT:

Getting the mean, X,  
  
X = Sum(x) / n  
Summing the items, Sum(x) =    56
As n =    6
Thus,  
X =    9.333333333 [ANSWER]