A gene involved in neural development shows three times as many synonymous site

Question

A gene involved in neural development shows three times as many synonymous site substitutions than nonsynonymous ones. A likely explanation is that this gene -has a very high mutation rate. -is affected by heterozygote advantage. -is a neutral gene. -is under positive selection. -is under purifying selection A gene involved in neural development shows three times as many synonymous site substitutions than nonsynonymous ones. A likely explanation is that this gene -has a very high mutation rate. -is affected by heterozygote advantage. -is a neutral gene. -is under positive selection. -is under purifying selection

Explanation / Answer

-is under purifying selection

Synonymous substitutions are silent means the mutation which will not going to change encoded amino acid, whereas the non-synonymous substitutions are missense, here the mutation will change the encoded amino acid, it might be neutral or harmful or helpful to the species based on the outcome. Here the gene which is involved in neural developed is showing 3 times synonymous site substitution than nonsynonymous ones, this shows the gene is under purifying selection.

Ka/Ks ratio= No. of nonsynonymous substitutions per non-synonymous site (Ka)/No. of synonymous substitutions per synonymous site (Ks)

Less than 1 Ka/Ks ratio will indicate purifying selection.

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