The positive selection process for T lymphocytes that occurs in the thymus invol

Question

The positive selection process for T lymphocytes that occurs in the thymus involves selection of T lymphocytes that a. Have a high affinity for MHC b. Have a high affinity for MHC and self peptide c. Have a low affinity for MHC and self peptide d. Have a low affinity for MHC The positive selection process for T lymphocytes that occurs in the thymus involves selection of T lymphocytes that a. Have a high affinity for MHC b. Have a high affinity for MHC and self peptide c. Have a low affinity for MHC and self peptide d. Have a low affinity for MHC a. Have a high affinity for MHC b. Have a high affinity for MHC and self peptide c. Have a low affinity for MHC and self peptide d. Have a low affinity for MHC

Explanation / Answer

b. Have a high affinity for MHC and self peptide

Explanation:

Positive selection occurs when double positive T cells bind cortical epithelial cells expressing Class I or Class II MHC plus self peptides with a high enough affinity to get the survival signal.

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