3. Ten patients with advanced diabetic nephropathy (kidney complications of diab
ID: 3039807 • Letter: 3
Question
3. Ten patients with advanced diabetic nephropathy (kidney complications of diabetes) were treated with captopril over an 8-week period. Urinary protein was measured before and after drug therapy, with the results listed below. a. What’s the appropriate statistical procedure to test whether mean urinary protein has changed over the 8-week period? b. Use Stata to perform the test in (a) using both the raw and natural log (i.e. ln) scale, and report a p-value. Are there any advantages to using the raw or the ln scale? c. What’s your best estimate of the percentage change in urinary protein based on the given data? d. Provide a 95% CI associated with your estimate in (c). Patient Raw scale urinary protein ln scale urinary protein Before After Before After 1 25.6 10.1 3.24 2.31 2 17.0 5.7 2.83 1.74 3 16.0 5.6 2.77 1.72 4 10.4 3.4 2.34 1.22 5 8.2 6.5 2.10 1.87 6 7.9 0.7 2.07 -0.36 7 5.8 6.1 1.76 1.81 8 5.4 4.7 1.69 1.55 9 5.1 2.0 1.63 0.69 10 4.7 2.9 1.55 1.06
Explanation / Answer
In this study we want to check the mean urinary protein of patient has changed or not after taking druge in the 8-week period.
When we want to check the differance between two group or comparitively study that time alwayes use T-test.
Hypothesis:
H0 : Mean of urinary protein has same before and after taking of druge therapy during the 8-week period.
against,
H1 : Mean of urinary protein has differant before and after taking of druge therapy during the 8-week period .
Test Statistic:
One Sample t-test
t = 7.2929, df = 48, p-value = 2.619e-09
Decision Rule : The p-value is less than 0.05. So reject the null hypothesis.
Means, The Mean of urinary protein has differant before and after taking of druge during the 8-week period .
The 95 percent confidence interval:
( 3.597713, 6.336573 )
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