A single nucleotide addition and a single nucleotide deletion approximately 15 b

Question

A single nucleotide addition and a single nucleotide deletion approximately 15 bases apart in the DNA cause a protein change in sequence from Phe-Ser-Pro-Arg-Leu-Asn-Ala-Val-Lys (sequence 1) Phe-Val-His-Ala-Leu-Met-Ala-Val-Lys (sequence 2) Which of the following mRNA sequences could encode sequence 2? (Use the codon dictionary in Figure 9-5.) Second letter UGU Tyr UGC u UUC UAA Stop UGA Stop A UAG Stop UGG Trp G CUC CCA Pro CAc His CGU Gin cGG AGU AGA AUU AUC 11e ACC AUG Met ACG GUU Thr AAA AAC Asn AAG/Lys GAU GACAsp GAA GGU GGA Gly O UUU UCA CCC AGG UUA AAU GCC GUU AAA O UUG GUG CAC GCG CUU AUG GCG GUG AAG O UUU AGU CCA CGC CUU AAU GCA GUC AAA O UUC GUC CAC GCC UUA AUG GCU GUA AAG

Explanation / Answer

Answer: UUC GUC CAC GCC UUA AUG GCU GUA AAG

Explanation: mRNA is called messenger RNA. This mRNA sequence in the genome helps in encoding the protein sequence. Form DNA sequence mRNA sequence is transcribed and from mRNA sequence, the protein sequence is transcribed to form the function unit protein for the function of the cell. The protein sequence is made of amino acid. For the transcription process mRNA uses codon to generate protein sequence. These codons are the sequence of nucleotide, where three nucleotide makes a codon. Each codon represents an amino acid which together makes the protein sequence. The polymer of amino acid together makes the functional protein sequence in a cell. Hence, the codon UUC represents Phe, GUC represents Val, CAC represents his, GCC represents ala, UUA represents Leu, AUG represents met, GCU represents ala, GUA represents Val, AAG represents lys.

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