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Most vaccines in use today work by inducing humoral immunity. This is so because

ID: 302524 • Letter: M

Question

Most vaccines in use today work by inducing humoral immunity. This is so because: a. go. Antibodies are the only immune mechanism that prevents infections, by neutralizing and clearing microbes before they gain their foothold in the host Several boosters are given to the immunized person to that high tifters are achieved Extracellular bacteria are the most prevalent microbial infections found in the clinic today Antibodies are longer lived that any T cell subset from the adaptive immune system b. c. d. 31. Vaccines are effective if: The infectious agent establishes latency in its host The infectious agent undergoes substantial antigenic variation a. The infectious agent does not interfere with the host immune response All of the above c. b. d. 32. Which of the following is NOT an established or approved vaccine approach? a. b. Live attenuated or killed bacteria vaccines Live attenuated or killed virus vaccines DNA-based vaccines Bacterial vector vaccines C. d. 33. Viral vaccines often induce long-lasting specific immunity, so immunization of children is sufficient for lifelong protection. However, the following type of viral vaccination approach may cause infection in immune-compromised ndividuals: a. Viral vector vaccines b. Live attenuated viral vaccines Synthetic viral vaccines Conjugate vaccines c. d. 34. Transfer of specific antibodies can also confer protective immunity. This type of immunity is known as Externally acquired immunity Adoptive transfer c. a. Active immunity b. Passive immunity d. 35. In transplantation immunology the term "transfusion" generally refers to: The infusion of HLA matched leukocytes into an allogeneic recipient The transfer of circulating blood cells or plasma from one individual to another The transfer of short-lived red blood cells (RBCs) None of the above a. b. c. d. 36. is the process of taking cells, tissues, or organs, called afrom one individual and placing them into a (usually) different individual. a. Transfusion; blood unit c. Transplantation; graft d. Anastomoses; inoculum b. Extirpation; graft Transplantation of cells or tissues from one individual to a genetically non-identical individual invariably leads to: a. Surgical failure of the graft b. Long-life tolerance to the graft 37. c Immune-mediated rejection of the graft d. Necrosis of the grafted tissue 38. Not ALL self-reactive T cells are eliminated during development. Which of the following is true concerning some CD4*T cell populations that are capable of "seeing" self antigen in the thymus? a. Are not deleted but instead differentiate into regulatory T cells specific for these antigens b. Are forced to revert to a less mature stage and undergo commitment to the CD8 T lineage c. Move into the bone marrow where they assist in B cell poiesis d. None of the above

Explanation / Answer

30. A vaccine triggers cell production similar to that which would occur during a primary response. In doing so, the patient is able to mount a strong secondary response upon exposure to the pathogen. So several boosters are give to the immunized person in order to generate high titers of the antibody in the circulation.

31. Vaccines are effective when the infectious agent establishes a latency in the host by which the antigen is expressed to the B cell throughout the persistence time in the host. This will help make high tiers of antibodies against the pathogen.

32. Bacterial vector vaccines are not used as preferred mode for vaccination, as these plasmids cannot be expressed in the eukaryotic host to generate a immune response.

33. Killed or live attenuated vaccines are effective mode of vaccination for immuno compromised patients.

34. The immunity is called passive immunity which can occur naturally when maternal antibodies transferred to the fetus through the placenta and it can also be induced artificially.

35. The transfusion refers to HLA matched leucocytes being transferred to an allogenic recipient.

36. Transplantation is the process of taking cells, tissues or organs called a graft from on eindividual and placing them into a different individual.

37. These T cells differentiate into T regulatory cells which are able to maintain tolerance in the host by seeing self antigens.

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