Question: A cell can initiate both pro- and anti- apoptotic signals in response

Question

Question: A cell can initiate both pro- and anti- apoptotic signals in response to a stimuli. Given each scenario, choose the most likely protein to counteract the “cell death signal” and save the cell. To save the cell you must choose the best strategy (Best = most direct, so if we disrupt A we should fix A or possibly B instead of trying to fix D.) Pick a strategy for the scenario:

1.Activated Caspase 9

2.Activated Bax and Bak

3.Release of cytochrome C in the cytosol

4.Caspase mediated DNA double stranded breaks

5.Apoptosome formation

6.Death ligand expression in neighboring cells.

options for each senario:

a.Bcl2 - stabilizes mitochondrial outer membran.

b. IAPs - target caspases for degradation

c.There is no hope of cell survival

d.Stabilize the cell membrane

e.Block death receptor trimerization.

a.Bcl2 - stabilizes mitochondrial outer membran.

b. IAPs - target caspases for degradation

c.There is no hope of cell survival

d.Stabilize the cell membrane

e.Block death receptor trimerization.

Explanation / Answer

Actually, apoptosis starts when cytochrome c releases to the cytosol from the mitochondria. After that, many other processes like caspase cascade and Bcl2 pro apoptotic protein start. In the activation of Bcl2 protein occurs due to activation of BAX, BAK, and BOK proteins, which later on trimerization kills the cell. Therefore, to prevent the apoptosis Bcl2 protein activation is must.

Answer -therefore, we choose the strategy number 3. Now we choose scenario ‘a’ and ‘e’ to complete the strategy.

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