Does infection with HIV-2 slow the pro- * gression to AIDS for those with HIV-1?
ID: 3019986 • Letter: D
Question
Does infection with HIV-2 slow the pro- * gression to AIDS for those with HIV-1? A blood test is used to de-
termine whether a person is infected with HIV. If a person has AIDS, it means the person is experiencing symptoms that result from the HIV infection. (It is possible to be infected with HIV and not show symptoms.) Read the extract given, and then answer the questions that follow it. (Source: Esbjornsson et al., Inhibition of HIV-1 dis- ease progression by contemporaneous HIV-2 infection, New England Journal of Medicine, vol. 367: 224–232, July 19, 2012)
Methods We analyzed data from 223 participants who were infected with HIV-1 after enrollment (with either HIV-1 infec- tion alone or HIV-1 and HIV-2 infection) in a cohort with a long follow-up duration (approximately 20 years), according to whether HIV-2 infection occurred first and the time to the development of AIDS (time to AIDS)....
Results The median time to AIDS was 104 months in partici- pants with dual infection and 68 months in participants infected with HIV-1 only.... Participants with dual infection with HIV-2 infection preceding HIV-1 infection had the longest time to AIDS....
Identify the treatment variable and the response variable.
Was this a controlled experiment or an observational study? Explain.
What do the median times to AIDS show, descriptively?
Can you conclude that the presence of HIV-2 slows the progression of HIV to AIDS? Why not?
Explanation / Answer
Was this a controlled experiment or an observational study?
OBSERVATIONAL STUDY BECAUSE WE ARE JUST SEEING THE ACTIONS AND THE CONSEQUENCES FOR EACH INFECTION, WE ARE NOT INTERVIEWING IN THE PROCESS
Can you conclude that the presence of HIV-2 slows the progression of HIV to AIDS?
No, we cant
because we have not enough data for doing inferences
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