Q4 A test for a certain infection was evaluated experimentally. When administere

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Q4 A test for a certain infection was evaluated experimentally. When administered to a test group of 285 individuals known to have the infection, the test was positive in 256 cases. The test was also to a control group of 220 subjects known to be free of the infection. The test was positive in 12 cases. 1. Estimate the sensitivity and specificity of the test directly from the data 2. This test is intended to be used in clinical populations of varying infection prevalence. Use R to construct plots of PPV and NPV for values of prevalence ranging from 0 to 10%. Use the type- '1' option of the plot) function. 3. Calculate prevalence, NPV and PPV directly from the data. How do these values compare to those shown in the plots of part (b)?

Explanation / Answer

Reference standard is positive Reference standard is negative Test is positive 256 12 Test is negative 29 208 Sensitivity: 0.8982 Specificity: 0.9455

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