You look at the location of commonly know cancer genes in tne two cell lines by

Question

You look at the location of commonly know cancer genes in tne two cell lines by analyzing genetic marker and you determine that there is a loss of heterozygosity on chromosome 13 only in the cancer cells.Using a virus you introduce a wild-type copy of a gene from chromosome 13 known to be involved in carcinogenesis into the cancer cell line.

You find that introduction of this gene copy slow down the rate of cell division in the cancer line

Which of these hypotheses is suggested by this observation?

1)an apoptotic factor that is mutated in the cancer cell line

2)an oncogene that is mutated in the cancer cell line

3)a tumor suppressor gene that is mutated in the cancer cell line

4)a gene coding for a DNA repair protein that is mutated in the cancer cell line

5)a gene required for metastasis

6)a gene required for angiogenesis

Explanation / Answer

3)a tumor suppressor gene that is mutated in the cancer cell line.

Loss of heterozygosity is one of the common events which occurs in several form of cancer. A tumor suppresor gene may lost one allele which is functional for the gene, as a result the tumor suppresor function get lost.

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