Part ll- Regulation Questions Blood ph is normally regulated by the respiratory

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Part ll- Regulation Questions Blood ph is normally regulated by the respiratory pystem to control the level of Co, e) and by the urinary system to control the levels of HCO, and non-volatile acids in the blood. Metabolism Tubular lumen CO2 Tissue Proximal renal Tubular cell CO2 + HO-CO2 + H2O Carbonic Blood Alveolus (in lungs) O2+ H2O cos e the n enico, a) Ehco, (a) He (g). wha cfecr would each of the following have on blood pH? Explain with LeChatlier's principle. a. Hyperventilating b. Holding your breath for an extended period of time C. Excessive ingestion of baking soda, HCO, d. Inhibiting renal carbonic anhydrase 4. Mary has an acid-base disturbance that is being compensated for with another body system. Identify the ype of disturbance and trace our the physiological pathway responsible for the s. For each of the treatments listed below, indicate whether you would recommend it (yes) or not corect Mary's problem? Explain what effect ach treatment would have upon her blood a. Breathing in a paper bag b. An IV containing pure HCO, in an isotonic solution c. Holding her breath for as long as she can d. An IV containing pure CO, in an isotonic solution pH. Tidle block illustration: ODawm Hadson - Fotolia.com. Case copyright held by the National Center for Case Science, Univensity at Buffalo. S n eines, which ourline our policy coreproduction of this wok, 2009, Plese ses Scate Univensity of New York. Orignally published December 28 Case One Headache Afer Another Biochemistry Edition' by Taylor &C;

Explanation / Answer

3) Le-Chatlier principle is used to predict the effect of changes in conditions on chemical equilibrium.

a) Hyperventilation results in carbon dioxide washout. This decreases the amount of carbonic acid in blood. The blood becomes less acidic and therefore pH of the blood increases.

b) When breath is hold for an extended period of time, the concentration of carbon dioxide in blood increases which in turn gets converted to carbonic acid. This decreases the pH of blood.

c) When excessive amounts of baking soda, HCO3 are ingested, the concentration of OH (hydroxyl) ions increase which raises the alkalinity and pH of blood.

d) Carbonic anhydrase is responsible for urinary acidification and bicarbonate reabsorption. So, inhibiting carbonic anhydrase results in poor reabsorption of bicarbonate. So, alkalinity and the pH of the blood will decrease.

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