Please help on this. I’m quite stuck between the choices Which of the following
ID: 279781 • Letter: P
Question
Please help on this. I’m quite stuck between the choices Which of the following statements is correct about nuclear import and export? O Ran-GTP is required for the unloading of cargo from importin and also for the binding of exportin to their cargo. O Ran-GDP is required for the unloading of cargo from importin and also for the binding of exportin to their cargo. O Ran-GTP is required for the unloading of cargo from importn and Ran-GDP for the binding of exportin to their cargo. O Ran-GDP is required for the unloading of cargo from importin and RAN-GTP for the binding of exportin to their cargo.
Explanation / Answer
Right answer is 1st one not the 3rd one as you have highlighted
Ran-GTP is required for the unloading of cargo from importin and also for the binding of exportin to their cargo
Overall it can be represented as: Importin+ Ran-GTPàrelease cargo; Exportin+ Ran-GTPßattach cargo
On cytoplasm side importin is with Ran-GDP upon entering nucleoplasm side GDP converts to GTP and cargo is released. On nucleoplasm side exportin is gets attached to Ran-GTP this brings about conformational change to get attached with cargo upon entering cytoplasm side GTP converts to GDP and cargo is released.
Importins release cargo upon binding to RanGTP, while exportins must bind RanGTP to form a ternary complex with their export cargo.
Hope understood!!
good luck!
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