Mutations in genes that encode for proteins in the EGFR signaling pathway are co
ID: 279444 • Letter: M
Question
Mutations in genes that encode for proteins in the EGFR signaling pathway are commonly associated with cancer, since over-activation of this pathway can lead cells to divide uncontrollably. "Gain of function" mutations lead to increased activity of a particular enzyme, while loss of Which type of mutation in the following proteins would be associated with cancer? Drag and drop the correct answer next to each enzyme Each option may be used once, more than once, or not at all. RAS GAP -catalyzes the hydrolysis of Ras-bound GTP into GDP MEK phosphatase - an enzyme that dephosphorylates MEK ERK loss of function function 2 abQW ERTExplanation / Answer
A) Usually RAS is active when it is bound to the GTP (RAS-GTP) and incative in RAS-GDP form. The function of RAS-GAP is to convert RAS-GTP to RAS-GDP that means the inactivation of the RAS. So loss in function of the RAS-GAP keeps the RAS in its GTP bound state (RAS-GTP) which is the active state of the the RAS,that inturrn leeds to the activation of its downstreem signaling protein continously and pramotes uncontrolled cellular prolifiration.
B) MEK is one of the downstreem ragulators of the RAS pathway.MEK is active in it is phosphorylated state and inactive in its dephosphorlyted state.
A loss of function mutations in MEK phosphatase keeps the MEK in its phosphorylated active state this inturn leads to the continues activation of its downstreem targets and leads to the uncontrolled cell prolifiration.
C) A gain in function mutation in ERK which keeps it in its active state leades to the uncontrolled cell frolifiration.
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