Mutations in key genes and pathways in pancreatic cancer The upper panel shows n
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Question
Mutations in key genes and pathways in pancreatic cancer
The upper panel shows non-silent single nucleotide variants and small insertions or deletions. The central matrix shows: non-silent mutations (blue), copy number changes (amplification (>5 copies) represented in red and loss represented in green) and genes affected by structural variants (SV, yellow). Pathogenic germline variants are highlighted with asterisk (*) symbols. The histogram on the left shows the number of each alteration in each gene.
Question: Explain what specific data is shown in the figure above in regards to genetic heterogeneity. Also, please explain the primary challenge when identifying driver mutations in high through put sequencing datasets. Thank you!
Germline pathogenic Amplification (oopy number > 5) Non-silent SNVindel+amplificationS Non-silent SNV or indel Loss (copy numberExplanation / Answer
Ans- the above figure is showing some data which include the data for silent and non silent mutations which are associated with a specific disease that is pancreatic cancer.
The main problem occur during the sampling and processing of sample because it may produce some errors which may alter our results and it become difficult to observe the driver mutations.
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