s New... 14 5) Describe the molecular processes that underlie LTD, and how does

Question

s New... 14 5) Describe the molecular processes that underlie LTD, and how does LTD affect the postsynaptic potential at the synapse. 6) How is a neuron's birthdate related to its cortical location? Describe a way you could determine this experimentally. 7) A young patient is brought to the doctor because of failure to thrive and is diagnosed with lissencephaly. Disruption in what signals, involved in what process, would cause this diagnosis. 8) What is Hebb's postulate? How does this concept explain the vast potential for learning during the early postnatal period? P) What is a critical period? Give two examples. How would you test for the presence of a critical period?

Explanation / Answer

5). Long-term potentiation (LTP) is a phenomenon of formation or strengthening of new synapses with repeated stimulation of excitatory-neurons. It is the underlying mechanism of long-term memory.

Long-term depression (LTD) occurs due to the repeated low-frequency stimulation of the neurons. Means, the post-synaptic Ca+2 increases, but the frequency of the stimulus decreases. This pattern of stimulation causes reduced excitatory post-synaptic potential, which leads to LTD.

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