Scientists used the sevenless regulatory region to express transgenic RasG12V, w

Question

Scientists used the sevenless regulatory region to express transgenic RasG12V, which is a hypermorphic mutant allele of the ras gene. These transgenic animals have ommatidia that have excessive cell proliferation, resulting in a rough eye phenotype. They used this mutant to perform a modifier screen to find more genes that function in the sevenless pathway. What do you think would happen if, instead of using a transgenic approach that limits RasG12V to photoreceptors, scientists tried to create mutant flies that had the G12V mutation directly incorporated into the native ras locus?

a. You would get the same result - in hindsight, the scientists went through too much trouble and probably didn't need to go through the trouble for their modifier screen. b. Since ras is widely used to control cell proliferation in many tissue types, this might result in flies that have plieotropic effects and might not be useable (e.g., the flies might be dead). c. The eyes would grow elsewhere on the body, much like a homeotic transformation. . d. If they incorporate the G12V mutation into the native locus, it would no longer be a hypermorphic allele - it would become a hypomorphic allele.

Explanation / Answer

hypermorphic allele mutation shows increased function whereas, hypomorphic alleles results in loss of function of a partcular gene function.

d. If they incorporate the G12V mutation into the native locus, it would no longer be a hypermorphic allele - it would become a hypomorphic allele.

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