Scenario: For our project we use cultured mechanosensory neurons. These neurons

Question

Scenario: For our project we use cultured mechanosensory neurons. These neurons are well established model cells with intracellular and extracellular ionic environments known (listed in Table 1). Previously you calculated important parameters like equilibrium potentials (E) for Na, K", ???*, Mg2., and Cl, and the membrane resting potential (VM) (Table 2, use the listed numbers!). All experiments are carried out at 30 'C. Goal of you study is to determine the nature of mechanically activated ion channels (MACs) fond in these neurons. The drugs TTX (to block voltage-gated Na-channels) and TEA (to block voltage-gated K'-channels) has been applied to prevent voltage-gated channels to open and influence the observed MAC-currents. lon Extracellular Concentration XJouT 240 mM 8.5 mM 5 mM 6 mM 580 mM Intracellular Concentration Membrane Permeability P in resting neuron XIN 37 mM 340 mM 0.02 mNM 0.08 mM 55 mM Na* K' Ca 10 100 Not significant Not significant Cl Table 1 Intracellular and extracellular ion concentrations, and membrane ion permeabilities of the resting cell membrane of mechanosensory neurons (from Assignment #1), we can assume that ion concentration do not change during the experiments. No+ K+ Eco2. EMg2 CI. +0.0488 V 0.0963 V 0.0721 V +0.0564 V 0.0622 V 0.0616 V +48.8 mV -96.3 mV 72.1 mV +56.4 mV 62.2 mV 61.6 mV Table 2: Equilibrium potentials and membrane resting potential of mechanosensory neurons. Use the numbers listed in Table 2, not the ones you calculated in the first assignment. They may be the same or similar, but we want to make sure everyone uses the same starting point.

Explanation / Answer

The type of ion channel is TECK 1 which is a mechanically gated K+ channel.

It is selective for K+ ions.

They are normally found in the mammalian neurons of the central nervous system. They help in the K2P channel expression of the sensory neurons as well as motor neurons. They are potentially excited by the polyunsaturated fatty acids.

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