Academic Integrity: tutoring, explanations, and feedback — we don’t complete graded work or submit on a student’s behalf.

1. During _____________________ [name stage of replication], hemagglutinin prote

ID: 274628 • Letter: 1

Question

1. During _____________________ [name stage of replication], hemagglutinin

proteins binds sialic acid molecules on the __________________ [name specific

structure of host cell] of the respiratory cell.

2. During penetration and __________________ [name stage of replication], the virion

enters the cell by ______________________________ [name cellular process]

and is released into the cytoplasm of the cell following the fusion of the viral membrane with

the __________________ membrane; the capsid is subsequently removed.

3. During biosynthesis, the eight __________________ [positive or negative] – strand

_________ [DNA or RNA] genome segments enter the __________________

[name host cell structure] where the genome is replicated using the viral enzyme

________________________ [name specific enzyme]. This activity will produce

genome copies and __________________ [name macromolecule] that will be

translated to produce viral structural proteins.

4. During assembly, viral surface proteins that were exported to the ________________

[name host cell structure] aggregate with other viral proteins and genome copies.

5. During __________________ [name stage of replication], infectious virions are

released from the host cell by the process of __________________ [name process],

acquiring its __________________ [name viral structural component] from the host

cell as it leaves.

Explanation / Answer

1. During adsorption stage , hemeagglutinin protein binds to the sialic acid molecules on the epithellium of the respiratory cell.

2. During penetration and host cell entry , the virion enters the cell through endocytosis.

3. During biosynthesis , the eight segments of - strand RNA genome enter the cytoplasm of the host cell membrane where the genome is replicated using viral enzyme Replicase . This activity will produce genome copies and mRNA that will be translated to produce viral proteins.

4. During assembly , the viral surface proteins are exported to the cell surface , aggregate with other viral proteins and genome copies .

5. During release stage infectious virions are released from the host cell by the process of exocytosis acquiring its nucleocapsid structure from the host cell as it leaves.