12.When macrophages in the lung are infected with an intracellular bacterium, su

Question

12.When macrophages in the lung are infected with an intracellular bacterium, such as Mycobacterium tuberculosis, they are activated by the interactions of their pattern recognition receptors with the microbe. These activated macrophages will then: A. Migrate to the marginal sinus of the draining lymph node to activate naive CD4 T cells B. Increase their phagocytic properties to scavenge dead and dying neighboring cells C. Migrate to the liver where they will remove dying cells from the blood D. Migrate to the red pulp of the spleen where they will remove immune complexes from the circulation E. Up-regulate MHC class II and B7 molecules to amplify CD4 T cell responses in the lung

Explanation / Answer

E. Upregulate MHC class II and B7 molecule to amplify CD4 Tcell responses in the lung.

The bacteria is degraded by the macrophages and the peptide portions are presented by the MHC II or B7 receptors in the plasma membrane of the cells, these peptide molecules gets attached to the Tcell receptors and activates the CD4 tcells which in turn activates the adaptive immune response to kill the bacterial population further.

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