)Errors dur ing DNA replication can spontaneously create some indel mutations ae
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Question
)Errors dur ing DNA replication can spontaneously create some indel mutations aen a ite an explanation to show how an insertion might be spontancously created if there are tandem repeats. 3 points) b) Draw and explain how a deletion might be spontaneously created if there are tandem repeats. (3 points) c) What is the name for the kind of occurrence during replication that causes an indel mutation? (1 points) frameshift mutahsm d) What are two human diseases that result from expanded trinucleotide repeats? (2 points) - fragile x-sypdrp me e) Describe two different ways that expanded trinucleotide repeats can result in an allele that causes a human disease. (5 points)Explanation / Answer
Answer 1)a)
Short tandem repeats(STRs) are responsible for any kind of mutation happens in tandem repeats.
STR----->replication slippage----> post replication repair
suposese the STR is CAT CAT then after insertion the sequence will become
CATCAT ------> CAT TTA CAT
1)b)
STRs are microsatllites and generally 100 bp long
CAT CAT ----> CCAT
From the sequence AT got deleted
C) frameshift mutation
D) Hungtinton's disease 4 chromosome is affected and Fragile X syndrome here X chromosome is affected
In Friedrich's ataxia 9 chromosome is abnormal.
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