12 pts D Question 24 Problem #4 You are working on developing some novel chemoth
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12 pts D Question 24 Problem #4 You are working on developing some novel chemotherapy agents for an aggressively dividing new type of breast cancer. The following drugs have already been FDA approved for various other reasons, and thus could easily be used for a pilot human study. Looking at the mechanism of action (how these drugs work), your job is to briefly explain how and why each drug has chemotherapy potential. (:3 sentences per drug. 3 points per drug.. make sure you take it full circle and ACC: increases transcription of p53 AnnoyedGrunt: deactivates the Cdk-cyclin comple Bustin: antagonizes/blocks the EGF receptor DearDinosaur: methylates the promoter for Ras HTML Editorg ?. e ??@ D-T T. 12pt ¥ Paragrap Proctorio is sharing your screen. Stop sharing Hide 8Explanation / Answer
ACVC: p53 is tumor suppressor gene. Expression of this gene enhances the synthesis of p53 protein which enhances the apoptic action in cancerous cell and thus inhibit the growth of cancerous cells. The expression of gene occurs via the process of transcription and translation and thus increase in transcription of p53 gene results in increased expression of this gene and corresponding protein.
Annoyedgrunt: Cdk-cyclin complex is cyclin dependent kinase-cyclin complex which play a major role in cell cycel and thus in cell division. This complex signal the cells that they are ready to pass into the next stage of cell cycle through phosphorylation. Binding of cycline to Cdk to kinase activating the Cdks to phosphorylate other molecules. Thus deactivation of this complex inhibit the progress of cell cycle and thus inhibit cell division. As we know, the cancerous cells divide uncontrollably, inhibition of this complex is benificial to inhibit uncontrolled division of cancerous cells.
Bustin: The metastasis (spreading) of cancer depends on the multiple interactions between cancer and host cells. The TGF?-EGFR signaling pathway between theses interacting host cells and cancer cells promote the growth and spread of cancer cells. Thus, antagonising/ blocking of EGFR signaling pathway inhibits the cancer growth.
DearDinosour: Ras are small GTPase proteins which play a major role in transmitting signals within cells leading to cell growth and cell division. Ras proteins are encoded by Ras gene. The methylation of promoter region of Ras gene does not allow RNA polymerase to bind with the promoter sequence. The binding of RNA polymerase is essential for transcription for this gene which ultimately gives Ras protein via the process of translation. Hence, methylation of promoter region of Ras gene inhibits the production of Ras protein and thus inhibition of growth and division occurs in cancerous cells.
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