9. What other factors may influence an individual\'s ability to clot properly? L
ID: 269654 • Letter: 9
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9. What other factors may influence an individual's ability to clot properly? Late-Onset Alzheimer's Disease Alzheimer's disease is the most common form of dementia worldwide. Alzheimer's disease currently affects an estimated 2.5 to 4 million Americans, and this number is expected to increase in the coming decades as more people are living longer. In general, individuals are estimated to have a 10% lifetime risk of developing dementia, with 60% of dementia cases being caused by Alzheimer's disease. Alzheimer's disease starts with subtle memory loss, increasing forgetfulness or mild confusion as the only symptoms. However, over time, memory loss progressively worsens to a point where it interferes with most aspects of daily Alzheimer's disease can be classified as early onset or late-onset, depending on whether symptoms appear before or after age 65, respectively. Early-onset Alzheimer's disease accounts for less than 5% of all cases and results from clearly inherited mutations, conversely, the development of late-onset Alzheimer's disease is thought to result from a combination of genetic, lifestyle and environmental factons 10. Late onset Alzheimer's disease is considered a mult-factorial trait. What are the other factors (apart from genetic causes) that contribute to an individuals overall risk? The exact cause of late-onset Alzheimer's disease is currently unknown. This form of the disorder probably results from a combination of genetic and environmental factors. A variant of the apopliprotein E gene, APOE, has been recognized and extensively studied as a genetic risk factor for the development of late-onset Alzheimer's disease. Three common variants of the APOE gene exist in the general population, called APOE E2, E3 and 84. APOE E3 is the most frequent variant in the general population. APOE E4 is common in Northern Eu APOE E2 is a rare vaniant. The APOE E4 variant has been consistently associated with an increased risk of developing late-onset Alzheimer's disease. More specifically, carrying a single rope, whereas of this allele increases the lifetime risk more than tenfold. On the other hand, carrying the APOE &2 allele may have a small protective effect against developing late-onset Alzheimer's disease in certain populations. How different APOE alleles exactly impact the risk of developing late-onset Alzheimer's disease is still unclear. The APOE gene encodes a protein that is a major constituent of lipoproteins, which a responsible for packaging and transporting cholesterol and other fats through the bloodstream and cerebrospinal fluid. Defects in lipid and cholesterol trafficking, or a defect in the production,Explanation / Answer
Other factors influencing blood clotting: According to some studies-
Other factors for late onset of Alzheimer's disease: According to some studies-
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