Find all possible pathogen associated molecular patterns (PAMPs) and their respe

Question

Find all possible pathogen associated molecular patterns (PAMPs) and their respective sensors as a table, including cell surface endosomal cytosolic sensors of PAMPs. Include human and mouse in your table. (YOU SHOULD MENTION TLR, NLR, CLR, and RLR)!!! Find all possible pathogen associated molecular patterns (PAMPs) and their respective sensors as a table, including cell surface endosomal cytosolic sensors of PAMPs. Include human and mouse in your table. (YOU SHOULD MENTION TLR, NLR, CLR, and RLR)!!!

Explanation / Answer

PRRs (structure)

Adapters (structure)

PAMPs/Activators

Species

TLR

TLR1–TLR2 (LRR–TIR)

MyD88 (TIR–DD), TIRAP (TIR)

Triacyl lipopeptides

Bacteria

TLR2–TLR6 (LRR–TIR)

MyD88 TIRAP

Diacyl lipopeptides

Mycoplasma

LTA

Bacteria

Zymosan

Fungus

TLR2 (LRR–TIR)

MyD88, TIRAP

PGN

Bacteria

Lipoarabinomannan

Mycobacteria

Porins

Bacteria (Neisseria)

tGPI-mucin

Parasites (Trypanosoma)

HA protein

Virus (Measles virus)

TLR3 (LRR–TIR)

TRIF (TIR)

dsRNA

Virus

TLR4 (LRR–TIR)

MyD88, TIRAP, TRIF, TRAM (TIR)

LPS

Bacteria

Envelope proteins

Virus (RSV, MMTV)

TLR5 (LRR–TIR)

MyD88

Flagellin

Bacteria

TLR7 (LRR–TIR)

MyD88

ssRNA

RNA virus

hTLR8 (LRR–TIR)

MyD88

ssRNA

RNA virus

TLR9 (LRR–TIR)

MyD88

CpG DNA

Bacteria

DNA

DNA virus

Malaria hemozoin

Parasites

mTLR11 (LRR–TIR)

MyD88

Not determined

Bacteria (uropathogenic bacteria)

Profilin-like molecule

Parasites (Toxoplasma gondii)

NALP1/NLRP1 (CARD–FIND–NBD–LRR-PYD)

ASC

Anthrax lethal toxin

Bacteria

IPAF/NLRC4 (CARD–NBD–LRR)

Flagellin

Bacteria

NAIP5 (BIRx3–NBD–LRR)

Flagellin

Bacteria

CLR

Dectin-1 (lectin–ITAM)

?-Glucan

Fungi

RLR

RIG-I (CARDx2–helicase)

IPS-1 (CARD)

RNA (5’-PPP ssRNA, short dsRNA)

Virus

MDA5 (CARDx2–helicase)

IPS-1

RNA (poly IC, long dsRNA)

Virus

LGP2 (helicase)

RNA

Virus

NLR

NOD1/NLRC1 (CARD–NBD–LRR)

RICK (CARD), CARD9 (CARD)

iE-DAP

Bacteria

NOD2/NLRC2 (CARDx2–NBD–LRR)

RICK, CARD9

MDP

Bacteria

NALP3/NLRP3 (PYD–NBD–LRR)

ASC (PYD–CARD) CARDINAL (PYD–FIND)

MDP

Bacteria

RNA

Bacteria, Virus

ATP

Bacteria? Host?

PRRs (structure)

Adapters (structure)

PAMPs/Activators

Species

TLR

TLR1–TLR2 (LRR–TIR)

MyD88 (TIR–DD), TIRAP (TIR)

Triacyl lipopeptides

Bacteria

TLR2–TLR6 (LRR–TIR)

MyD88 TIRAP

Diacyl lipopeptides

Mycoplasma

LTA

Bacteria

Zymosan

Fungus

TLR2 (LRR–TIR)

MyD88, TIRAP

PGN

Bacteria

Lipoarabinomannan

Mycobacteria

Porins

Bacteria (Neisseria)

tGPI-mucin

Parasites (Trypanosoma)

HA protein

Virus (Measles virus)

TLR3 (LRR–TIR)

TRIF (TIR)

dsRNA

Virus

TLR4 (LRR–TIR)

MyD88, TIRAP, TRIF, TRAM (TIR)

LPS

Bacteria

Envelope proteins

Virus (RSV, MMTV)

TLR5 (LRR–TIR)

MyD88

Flagellin

Bacteria

TLR7 (LRR–TIR)

MyD88

ssRNA

RNA virus

hTLR8 (LRR–TIR)

MyD88

ssRNA

RNA virus

TLR9 (LRR–TIR)

MyD88

CpG DNA

Bacteria

DNA

DNA virus

Malaria hemozoin

Parasites

mTLR11 (LRR–TIR)

MyD88

Not determined

Bacteria (uropathogenic bacteria)

Profilin-like molecule

Parasites (Toxoplasma gondii)

NALP1/NLRP1 (CARD–FIND–NBD–LRR-PYD)

ASC

Anthrax lethal toxin

Bacteria

IPAF/NLRC4 (CARD–NBD–LRR)

Flagellin

Bacteria

NAIP5 (BIRx3–NBD–LRR)

Flagellin

Bacteria

CLR

Dectin-1 (lectin–ITAM)

?-Glucan

Fungi

RLR

RIG-I (CARDx2–helicase)

IPS-1 (CARD)

RNA (5’-PPP ssRNA, short dsRNA)

Virus

MDA5 (CARDx2–helicase)

IPS-1

RNA (poly IC, long dsRNA)

Virus

LGP2 (helicase)

RNA

Virus

NLR

NOD1/NLRC1 (CARD–NBD–LRR)

RICK (CARD), CARD9 (CARD)

iE-DAP

Bacteria

NOD2/NLRC2 (CARDx2–NBD–LRR)

RICK, CARD9

MDP

Bacteria

NALP3/NLRP3 (PYD–NBD–LRR)

ASC (PYD–CARD) CARDINAL (PYD–FIND)

MDP

Bacteria

RNA

Bacteria, Virus

ATP

Bacteria? Host?

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