2. Background information: Polydactyly is an autosomal dominant condition and as

Question

2. Background information: Polydactyly is an autosomal dominant condition and assume it is NOT 100% Individuals can inherit the allele for polydactyly but have no extra fingers or toes. In the pedigree below, individuals colored in black show some degree of polydactyly, while those not colored in are PHENOTYPICALLY normal (no extra digits). Individuals 6 and7 were genetically tested and found to be homozygous normal. Individual #1 and WS are Individual #2 is homozygous normal. Answer the following questions: What is the probability that individual #4 is a carrier what is the probability that individual #4 is NOT a carrier By applying Bayesian analysis, what is the probability thatindi idual #8 has inherited the polydactyly allele? a) b) c) 2 3 5 Answer: is Carrier of allele is NOT carrier Prior probability Conditional probability (she has 2 unaffected kids) Joint Probability Posterior probability

Explanation / Answer

Gene responsible for polydactyly is a dominant gene with less than 100% penetrance.

1. With individual 2, 6 and 7 being homozygous normal and 1 and 5 being heterzygous for the gene. Probability for individual 4 of being a carrier is 50%

2. Probility of individual 4 not being a carrier is 50%

3. Using a Bayeisan statistics the probability og 8 being polydactyl is 33%.

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