1. The wobble hypothesis of Francis Crick concerns what association? A. specific
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1. The wobble hypothesis of Francis Crick concerns what association? A. specific pairing of purines with pyrimidines B. binding of large and small ribosimal subunits C. binding of codon with anticodon D. binding of tRNA with A-site on ribosomes E. specific binding of mRNA to ribosomes 2. What high-energy reaction mechanisms permit the "activation" of an amino acid with tRNA? A. adenylylation and hydrolysis B. hydrolysis and phosphorylation C. dehydrogenation and hydrolysis D. oxygenase and dehydrogenation E. reduction and phosphorylation 3. What reaction mechanism provides a role in bacterial cell proofreading during elongation, ensuringthe correct aminoacyl-tRNA is added to the A-site? A. phosphorylation from ATP B. peptide bond formation C. formation of a temporary disulfide bond D. adenylylation E. GTP hydrolysis 4. What happens if the mRNA terminates before a stop codon appears? A. Nothing, the polypeptide will just end. B. The ribosome complex will be stuck until the trans-translation rescue mechanism engages. C. A random tRNA with wobble properties will bind to terminate the polypeptide D. A tRNA specific for the stop codon will bind and terminate the polypeptide E. The ribosome will be stuck forever 5. Which of the following routinely change base-pair length with DNA replication, but without having an effect on DNA coding? A. plasmids B. telomeres C. intron:s D. transposons E. highly repetitive sequencesExplanation / Answer
1. Binding of codon with anticodon
2. adenylylation and hydrolysis
3. GTP hydrolysis
Both the EF-Tu–GTP and EF-Tu–GDP complexes exist for a few milliseconds before they dissociate. These two intervals provide opportunities for the codon-anticodon interactions to be proofread.
4. Nothing the polypeptide will just end
5. Telomeres
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