How will you create loss-of-function alleles of the mouse genes? Drag the terms

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How will you create loss-of-function alleles of the mouse genes?

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flanking an essential Hox7 Loss-of-function alleles of Hoxa7 and Hoxb7 could be created by performing gene knockouts for each exon gene. The gene knockout would be performed by creating a transgene that contains DNA corresponding to the internal region of an essential Hox7 éxon with a selectable marker in the place of an exon. A selectable marker would be included outside the DNA Injection of this construct into mouse cells and selection for the selectable marker and against the positive hegative egg selectable marker would yield clones containing the knockout of These cells would then be used to generate mice that carry the knockout construct in their cells sperm ES germ line at least one Hox7 gene both Hox7 genes

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