Limb development. It has been observed that four closely related species of liza

Question

Limb development. It has been observed that four closely related species of lizards differ in the number of digits that they possess. In trying to determine the molecular mechanism to explain this variation between the species, researchers found that the four species showed differences in the timing of Shh expression. The species with the most digits (D in the figure shown here) displays the longest duration of Shh expression. With what you know about the role moonwea0a2) Mperwan | KP-34314) I "N of Shh in limb development and autopod patterning, explain how a longer length of Sh each morph,the mais in expressiOn can result in an increased number of als. Phalangeal formulse are listed as described in Figure 1. digits (and a shorter length results in fewer digits). x03-40 X-34-5-3 2-34-4-3 Fig. 2. Adult manus and pes morphologies of (A) Hemiergis quadrilineata (2/2), (B) IH. peronii (3/3), (C) H peronii (4/4), and pes in the bottom row. Anterior is to the left and distal is up in all Scale bars-1mm

Explanation / Answer

Shh or sonic hedgehog is a protein secreted by shh gene involved in morphogenic activity in developing mammalian embroys. shh belongs to hedgehog family and its concentration and time dependent activity in ventral neural tube make it a perfect example of morphogen. it creates a developmental concentration gradient in neural tube, its activity is concentration and time dependent therefore, in D species the more digits are present due to longest shh expression during development

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