PLEASE ANSWER #25 22. Assume that the third codon within a particular ORF is AGA

Question

PLEASE ANSWER #25

22. Assume that the third codon within a particular ORF is AGA. Provide a singlebase substitution (point mutation) in this codon that causes a missense mutation AND ALSO is classified as a transition mutation?

AGA is converted to AAA lead to change of G by A change amino acid ( missense mutation)

Note - the most detremental type is nonsense mutation which lead to premature translation and defective proetin.

23. How many possible singlebase substitutions (point mutations) in the codon above would cause a silent mutation? Silent mutations that are possible in AGA without change in amino acid is 1(Arginine is coded by AGA or AGG).

24. Provide a singlebase substitution (point mutation) in the codon that would cause a nonsense mutation.A singlebase substitution would be A to U, AGA to UGA.

25. Of the mutations in questions 22-24, which would be the most detrimental to the gene product?

Explanation / Answer

25- the most detremental mutation is frame shift mutation as point mutation which change the whole reading frame will result in most misleading protein type where as missense or non sense will lead to change in only particular point in the chain .

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