1 You have a candidate gene which is likely expressed in the nucleus. Design exp
ID: 264988 • Letter: 1
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1 You have a candidate gene which is likely expressed in the nucleus. Design experiments to verify this using two different methods. 2. The cytoskeleton is a dynamic three-dimensional network of interconnected filaments and How does cytoskeleton control cellular tubules. What are the components of cytoskeleton? movement? Elaborate with two examples. 3. Please describe the formation and organization of protein macromolecules 4. A protein biochemist told a molecular geneticist that he had found a new mutant hemoglobin in which an aspartate was replaced by a lysine. The molecular geneticist expressed surprise, probably had doubt on the proposed mutation and sent his friend scurrying back to the laboratory (a) Why was the molecular geneticist dubious about the reported amino acid substitution? (b) Which amino acid substitution(s) would seem more reasonable to the molecular geneticist? Please answer with specific codon sequence(s) and briefly explain your answer Second Letter TAT Phe TCC TGC/ Cys TTA TTG TAA Stop TGA Stop A TAG Stop TGG Trp G CGT His CGC CAT Pro CTG AAT lle ACC ATA ATG Met ACG GTT GTA GAT GAA Gly GTG 5. Please discuss the possible ways in which nonsense mutations can potentially be suppressed in a cell 6. What is gene therapy? Compare and contrast the use of gene therapy and protein replacement therapy in treating genetic diseases. 7. What is/are the regulatory measures that monitor the development and manufacturing of biotherapeutics to ensure the safety and efficacy of the drugs? Briefly explain your answer 8. Write short notes on the structure of immunoglobulins (lg). Suggest 2 formats of recombinant antibodies which are designed based on the classical Ig structureExplanation / Answer
1 You have a candidate gene which is likely expressed in the nucleus. Design exp
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