wild-type rb protein can bind to protein E2F, sequestering it in the cytoplasm.

Question

wild-type rb protein can bind to protein E2F, sequestering it in the cytoplasm. When Rb protein is phosphorylated it releases E2F, allowing E2F to enter the nucleus, where it can activate transcription of genes needed for entry into S phase suppose the cell undergoes additional mutations, so that it becomes homozygous for loss of the Rb gene and homozygous for loss of the E2F gene. Would you consider this cell to be in increased danger of progressing toward cancer? Explain Suppose a different cell is heterozygous for a mutation in Rb such that the resulting protein remains bound to E2F even after the phosphorylation. Would you consider this cell to be in increased danger of progression towards cancer? Explain

Explanation / Answer

wild-type rb protein can bind to protein E2F, sequestering it in the cytoplasm.

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