Deletions can be used to map genes along a chromosome. In order to do this a ser
ID: 263803 • Letter: D
Question
Deletions can be used to map genes along a chromosome. In order to do this a series of crosses in which one parent is homozygous for a mutant allele is crossed with the other parent that is homozygous for a partial deletion of the region. The progeny are scored to determine whether they have the mutant phenotype ("m") or the wild-type phenotype ("+"). If a mutation falls within the deletion it will have the "m" phenotype, if it falls outside the deletion it will complement and have the ("+") phenotype. Some of the deletions will take out more than one gene and thus will produce the "m" phenotypes with several of the genes in question. Use the following table of progeny phenotypes for 7 different deletions to determine the order of the genes a-g on the chromosome.
mutations
deletion
a
b
c
d
e
f
g
1
+
+
m
+
+
+
m
2
+
+
+
m
m
+
+
3
+
+
+
m
+
m
+
4
+
+
+
m
m
m
m
5
+
m
m
+
+
+
m
6
m
+
m
m
m
m
m
7
m
+
+
m
+
m
+
The answer is afdegcb. Please EXPLAIN!
mutations
deletion
a
b
c
d
e
f
g
1
+
+
m
+
+
+
m
2
+
+
+
m
m
+
+
3
+
+
+
m
+
m
+
4
+
+
+
m
m
m
m
5
+
m
m
+
+
+
m
6
m
+
m
m
m
m
m
7
m
+
+
m
+
m
+
Explanation / Answer
Deletions can be used to map genes along a chromosome. In order to do this a ser
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