A protein is inserted in the ER membrane with type II topology (N -terminus in c

Question

A protein is inserted in the ER membrane with type II topology (N -terminus in cytosol). What mutation could invert the topology totype III (C-terminus in cytosol)?

a) The positively charged residues N-terminal of the Signal Anchorsequence need to be mutated and     positively charged residues C-terminal of the Signal Anchorsequence need to be added.
b) The positively charged residues N-terminal of the Signal Anchorsequence need to be mutated.
c) positively charged residues C-terminal of the Signal Anchorsequence need to be mutated.
d) None of the above.

Explanation / Answer

     b) The positively charged residuesN-terminal of the Signal Anchor sequence need to be mutated.      The N-terminal membrane flankingpositively charged Lysine and Arginine residues function assignals for establishing       the topological orientation.        Hope this served yourpurpose.

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