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a) What kind of general reaction is step 12? b) What metabolite(s) is/are consum

ID: 262638 • Letter: A

Question

a) What kind of general reaction is step 12?

b) What metabolite(s) is/are consumed as a nitrogen source in this pathway. How many total molecules of each source(s) are consumed to make one adenosylcobinamide?

SAH SAM H O 1,2 5,6 cobl (eoe) Urolll Precorrin-2 Precorrin-3A Precorrin-38 Precorrin-48 2SAH SAH 1 3 14 cobr 7) cobk (7) Precorrin-5X Hydrogenobyrinic Acid Precorrin-6X Precorrin-6Y Precorrin-8W Precorrin-8X M,0 Acenosine 4Glu ATP 19,20 16,17 16 (7) 1 5 cobo (cbtdt) cobC (cob0) cobs () cobT (7) 0 Carboxamide Cobyrinic Acid Adenosylcobyrinic Adenosylcobyric Acid Adenosylcobinamide Acid a,c-diamide

Explanation / Answer

A. 12 step was releasing the CO2 that called the decarboxylation reaction.

B.cyclic tetrapyrrolidine/pyrroline known as the corrin ring. Adenosylcobalamin (AdoCbl, also known as coenzyme B12) is the most complex coenzyme known, and its biosynthesis requires a great deal of genetic information. The core of AdoCbl is a cobalt-containing cyclic tetrapyrrolidine/pyrroline known as the corrin ring. The latter is synthesized only by prokaryotes via either of two pathways, the aerobic or anaerobic pathway, which differ in several important ways, but most notably in the timing of cobalt insertion (early in the anaerobic pathway, late in the aerobic pathway) and the type of cobaltochelatase used by each pathway.

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