22. Assume that the third codon within a particular ORF is AGA. Provide a single

Question

22. Assume that the third codon within a particular ORF is AGA. Provide a singlebase substitution (point mutation) in this codon that causes a missense mutation AND ALSO is classified as a transition mutation?

23. How many possible singlebase substitutions (point mutations) in the codon above would cause a silent mutation? Answer= Silent mutations that are possible in AGA without change in amino acid is 1(Arginine is coded by AGA or AGG).

24. Provide a singlebase substitution (point mutation) in the codon that would cause a nonsense mutation. Answer= A singlebase substitution would be A to U, AGA to UGA.

25. Of the mutations in questions 22-24, which would be the most detrimental to the gene product?

Explanation / Answer

22-AGA is converted to AAA lead to change of G by A change amino acid ( missense mutation)

Note - the most detremental type is nonsense mutation which lead to premature translation and defective proetin.

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