Match the following statements with the corresponding inhibitor. A transition st
ID: 260959 • Letter: M
Question
Match the following statements with the corresponding inhibitor.
A transition state analog.
A noncompetitive inhibitor.
A competitive inhibitor.
A suicide inhibitor.
A group specific inhibitor.
An uncompetitive inhibitor.
An affinity label.
Ion channels are transmembrane gates on the cell surface that allow ions to pass. Like an active site, the channel through the membrane is highly specific to the ion. It isregulated for ion size/diameter and specific charge. Na+ and K+ channels are essential to trigger neurons and muscles for contractions. Tetrodotoxin is a natural neurotoxin made by bacteria that are associated with many poisonous animals such as poison dart frogs, puffer fish, and the blue-ringed octopus. It is a large protein that binds at the periphery of the Na+ channel opening blocking the channel whether it currently contains a Na+ cation or not. When it binds, it paralyzes the victim for a substantial period of time, though victims often do recover. This allows the animal to either get away from a preditor or to obtain prey to eat alive. Though ion channels are not enzymes and do not catalyze a chemical reaction, so tetrodotoxin is not an enzyme inhibitor, tetrodotoxin acts like what type of inhibitor?
Acetyl-S-CoA and oxaloacetate are the two substrates that citrate synthase uses to generate citrate/citric acid and free S-CoA. The generation of citrate is the first step of the citric acid cycle. When ATP concentrations are high, ATP binds citrate synthase and slows it down. ATP is what type of inhibitor for citrate synthase?
Chymotrypsin is a protease that cuts other proteins after bulky hydrophobic amino acids. It particularly likes aromatics. Tosyl-l-phenylalanine chloromethyl ketone (TPCK) is an aromatic compound that binds the acitve site of chymotrypsin and TPCK then initiates a reaction to form a covalent bond inactivating chymotrypsin. TPCK is what type of inhibitor?
A.A transition state analog.
B.A noncompetitive inhibitor.
C.A competitive inhibitor.
D.A suicide inhibitor.
E.A group specific inhibitor.
F.An uncompetitive inhibitor.
G.An affinity label.
Ion channels are transmembrane gates on the cell surface that allow ions to pass. Like an active site, the channel through the membrane is highly specific to the ion. It isregulated for ion size/diameter and specific charge. Na+ and K+ channels are essential to trigger neurons and muscles for contractions. Tetrodotoxin is a natural neurotoxin made by bacteria that are associated with many poisonous animals such as poison dart frogs, puffer fish, and the blue-ringed octopus. It is a large protein that binds at the periphery of the Na+ channel opening blocking the channel whether it currently contains a Na+ cation or not. When it binds, it paralyzes the victim for a substantial period of time, though victims often do recover. This allows the animal to either get away from a preditor or to obtain prey to eat alive. Though ion channels are not enzymes and do not catalyze a chemical reaction, so tetrodotoxin is not an enzyme inhibitor, tetrodotoxin acts like what type of inhibitor?
-Acetyl-S-CoA and oxaloacetate are the two substrates that citrate synthase uses to generate citrate/citric acid and free S-CoA. The generation of citrate is the first step of the citric acid cycle. When ATP concentrations are high, ATP binds citrate synthase and slows it down. ATP is what type of inhibitor for citrate synthase?
-Chymotrypsin is a protease that cuts other proteins after bulky hydrophobic amino acids. It particularly likes aromatics. Tosyl-l-phenylalanine chloromethyl ketone (TPCK) is an aromatic compound that binds the acitve site of chymotrypsin and TPCK then initiates a reaction to form a covalent bond inactivating chymotrypsin. TPCK is what type of inhibitor?
Explanation / Answer
1) C. Competitive inhibitor
Tetrodotoxin is highly specific in binding to the sodium ion (Na+) channels in the cells. It acts as a competitive inhibitor by mimicking the Na+ ion and blocking the Na+ ion channels, thus preventing the flow of Na+ ions.
2) B. Non-competitive inhibition
ATP exhibited a weak competitive inhibition of acetyl-CoA; Inhibition of oxaloacetate binding by high levels of ATP is noncompetitive.
3) B. Non-competitive inhibition
Tosyl-L-phenylalanine chloromethyl ketone (TPCK) which is an analog for chymotrypsin which binds to the active site and reacts irreversibly with the histidine residue to inhibit the enzyme.
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