BRCA1 and BRCA2 are known as tumor suppressor genes. A woman\'s risk of developi

Question

BRCA1 and BRCA2 are known as tumor suppressor genes. A woman's risk of developing breast and/or ovarian cancer is greatly increased if she inherits a deleterious (harmful) BRCA1 or BRCA2 mutation. Men with these mutated genes also have an increased risk of breast cancer. Both men and women who have harmful BRCA1 or BRCA2 mutations may be at increased risk of other cancers. It was recently discovered that the BRCA2 deleterious effect was recessive. On the island of New Quinoa, in a population of 10 000 people, 5200 are homozygous for the normal BRCA2 gene, approximately what percent of the population is at risk of passing on a cancerous gene but not expressing one? Assume Hardy-Weinberg equilibrium.

a. 7.8% b. 27.9% c. 40.2% d. 52.0%

Explanation / Answer

d. 52.0%

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