1. (1pt each) The following diagram lists different classes of mutants found in
ID: 256635 • Letter: 1
Question
1. (1pt each) The following diagram lists different classes of mutants found in a temperature sensitive screen for defective secretion. Red dots represent proteins that are normally secreted but accumulate in different organelles when proteins in that class are mutated. Each of these classes includes many mutant proteins that function at similar steps in the secretory pathway to cause accumulation in the same organelle Class A Class B Class C Class D Class E ER Golgi Fate of Normal secreted secretion in the cytosol in rough ER in ER-to-Golgi in Golgi in secretory vesicles transport vesicles Defective function Transport into the ER Budding of vesicles from the rough ER Fusion of transport vesicles with Golgi from Golgi to secretory vesicles Transport from secretory vesicles to cell surface Please circle which class the following mutant proteins would belong to. efe A signal recognition particle unable to pause translation A v-SNARE on the plasma membrane unable to bind t-SNAREs A receptor in the trans-Golgi unable to bind to adapters COPII coat proteins aren't recruited by Sar1-GTP A t-SNARE on COPII coated vesicles unable to bind v-SNAREs A BCD E A BC DE ABC D E A BCD E A BCDEExplanation / Answer
A signal recognition particle unable to pause translation: A
A v-SNARE on the plasma membrane unable to bind t-SNARE (no infusion plasma membrane): E
A receptor in the trans-Golgi unable to bind to adapters (No infusion with Golgi): C
A COPII coat protein which isnt recruited by Sar1-GTP: A
A t-SNARE on COPII coated vesicles unable to bind to v-SNAREs : C
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