1. (1pt each) The following diagram lists different classes of mutants found in

Question

1. (1pt each) The following diagram lists different classes of mutants found in a temperature sensitive screen for defective secretion. Red dots represent proteins that are normally secreted, but accumulate in different organelles when proteins in that class are mutated. Each of these classes includes many mutant proteins that function at similar steps in the secretory pathway to cause accumulation in the same organelle Class A Class B Class C Class D Class E ER Golgi Fate of Normal secreted secretion inthe cytoso in rough ER in ER-to-Golgi in Golgi Accumulation Accumulation Accumulation Accumulation Accumulation in secretory transport vesicles Defective Trans into the ER Budding of vesicles from the rough ER Fusion of transport vesicles with Golgi Transport from secretory vesicles to cell surface port from Golgi to secretory vesicles Please circle which class the following mutant proteins would belong to. A signal recognition particle unable to pause translation A v-SNARE on the plasma membrane unable to bind t-SNAREs A receptor in the trans-Golgi unable to bind to adapters COPIl coat proteins aren't recruited by Sar1-GTP A t-SNARE on COPII coated vesicles unable to bind v-SNAREs ABCD E ABC DE ABCD E ABCD E A BC D E

Explanation / Answer

A signal recognition particle unable to pause translation – Mutant class A A v-SNARE on the plasma membrane unable to bind t-SNAREs – Mutant class E A receptor in the trans-Golgi unable to bind to adapters – Mutant class D COP II proteins aren’t recruited by Sar1-GTP – Mutant class B A t-SNARE on COP II coated vesicles unable to bind v-SNAREs – Mutant class C

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