The patient’s infection was cured with intensive drug therapy, and the patient w

Question

The patient’s infection was cured with intensive drug therapy, and the patient was discharged with a long-term prescription for a low dose antibiotic. Why is long-term low-dose antibiotic therapy necessary for this patient?

A 5-year-old girl was admitted to the hospital with a tender mass in the right upper quadrant of her abdomen, along with severe dyspnea, a persistent cough, and chest and abdominal pain She had a history of several bouts of pneumonia, starting at momths Chest X-ravs showed cloudy spots consistent with a lung infection. Sonography rerealed a liver abscess. The abscess was drained and a sample was cultured and examined by microscopy (seephoto). Note: the photo may look fuzzy when printed; be sure to look at the online version ] Blood tests revealed a white blood cell cmmt nf 12.1 × 109L (nonnal is 4-11 × 10,L). The ratio of neutrophils to lymphocytes was approximately 3:2 The serum IgG level was 16.5 mgmL, IgM was 2.5 mgmL, and IgA was 1.75 mgmL A sample of the patient's white blood cells was mixed with the fluorescent cye diavdrorhadamine (DHR) and with PNMA, asubstance that nonspecifically stimulates neutrophils (mimicking the response that occurs when a neutrophil encounters a pathogen). IfH.O, is produced in response to stimulation, DHR fluorescence increases. The white blood cells were analyzed before (Testing) and after the PMA stimulation Cell counts (number of cells) is plotted against DHR Auorescence for mhite blood cells obtained from a normal cantrol and from the patient Resting Stimulated with PMA Normal control 10 DHR 123 [Resting) DHR 123 (4) Patient HR 123 (Restingl

Explanation / Answer

According to the information, the patient here is a 5 year old child who is suffering from a chronic infection. As per the diagrammatic cell count, it can be clearly seen that the pattern of lymphocyte activation is strikingly different in this child as compared to normal individual. Whereas the normal individual shows a very high range of immune activation, this child is not showing the same effect due to infection. Thus, the patient is recommended on antibiotics but on a low dose for long term. The possible reasons for this type of regimen can be enlisted as below:

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