Which of the following statements best describes the clonal evolution of tumors?

Question

Which of the following statements best describes the clonal evolution of tumors? Tumor cells gain the ability to travel to other sites in the body, where they establish secondary tumors. Both oncogenes and tumor-suppressor genes contribute to cancer but differ in their modes of action and dominance. If one or more of the required mutations is inherited, fewer additional mutations are required to produce cancer, and the cancer will tend to run in families. Tumor cells acquire more somatic mutations that allow them to become increasingly more aggressive in their proliferative properties. Environmental factors can contribute to a cell becoming cancerous, and these factors may interact with genetic predispositions to cancer. Tumor-suppressor genes typically act in a manner. manner, and oncogenes typically act in a benign; malignant benign, clonal malignant; benign recessive; dominant dominant; recessive

Explanation / Answer

1 If one or more of the required mutations is inherited, fewer additional mutations are required to produce cancer, and the cancer will tend to run in families.

2 recessive, dominant

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