1.Which of the following functions are associated with SRP? Choose one or more:

Question

1.Which of the following functions are associated with SRP?
Choose one or more:

A.acting as a chaperone

B.bringing ribosome to FtsY

C.bringing ribosome to SecYEG translocon

D.stalling translation until ribosome brought to destination

E.recognizing signal sequence

F.targeting proteins for degradation

2. For a Gram-negative bacterium such Escherichia coli, the four major destinations for extracytoplasmic proteins (proteins not in the cytoplasm) are the plasma membrane, extracellular spaces, the outer membrane, and the_________.

A. not dependent of the linear sequence of amino acids.

B. not important for the function of the protein.

C. determined by the gene encoding that protein.

D. not influenced by posttranslational modifications.

A. Twin arginine translocase proteins

B. Ribosomal proteins

C. Chaperonins

D. Signal recognition particle proteins

A. binding to a variety of different –10 and –35 sequences.

B. allowing for binding of various enhancer proteins to aid initiation.

C. using alternate nucleotides to promote different genes.

D. bringing about an early termination due to hairpins in the message.

.

Explanation / Answer

1. SRP stands fror Signal Recognition Particle. It is a chaperone protein which identifies and targets signal peptide of secretory proteins as well as of membranes coming from the ribosome to their proper locations. The locations include plasma membrane etc. It froms a complex with ribosome nascent chain called RNC-SRP complex. It is found in prokaryotes like Sachharomyces cerevisiae. Hence, options A and E are correct

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