21. The pedigree below traces the I recessive allele (t) of tyrosinemia in a Can

Question

21. The pedigree below traces the I recessive allele (t) of tyrosinemia in a Canadian famity, wisich is caused by an ildren with tyrosinemia produce uriee that smells like cabbage, This is utosomal tyrosinemia because they are unable to break down the amino acid tyrosine, Tytosine accurnul kidneys, ultimately resulting in lethal side effects ates in the liver and a. Based on what you know about dominant and recessive alleles, if a disorder is caused by an a. aidomal t are the possible genotypes of an affected individual? b. Couple A/B, Couple C/D and Couple G/I all have the same genotype. What is it? c. Are there any instances in this pedigree of an affected chile d having parents who are not affected by the disorder? Ifs so, this type of disorder has the ability to skip gencrations A carrier is a person who carries the allele for the disorder but does not exhibit symptoms of the disorder. Put a star next to any carriers if there are any in this pedigree, d. Examine the pedigree above and t in general tends to be affected more? Males, fen he examples of other autosomal recessive pedigrees. Which gender e. ales, or are both affected equally below traces the occurrence of hemophilia, a sex-linked disorder, in the Russian Imperial Family. Hemophilia is a disorder in which the afflicted individual is unable to produce functional clotting proteins. Affected individuals are at much higher risk of bleeding to It is caused b chromosomes, and males (XY) only have one X chromosome. death, even from minor bumps or cuts. y a recessive allele (a) on the X-chromosome. Remember, females (XX) have two X If a disorder is caused by a sex-linked recessive allele: Circle the genotype for an affected male Circle the genotype for an affected female. ???? , X X" , ??". Xay, or y a. b. What is the genotype of Irene? What is the genotype of Alexis?

Explanation / Answer

21.

a. Recessive alleles always indicate generation skipping. If its is autosomal or X-linked recessive, generation skipping is always shown. As the disorder is due to recessive allele so the genotype will be tt (homozygous recessive).

b. All the given couples are in heterozygous condition. So the genotype will be Tt.

c. Yes. There are many instances of generation skipping.

d. The carriers are A*, B*, C*, D*, E*, F* etc.

e. Other autosomal recessive pedigree of the roller tongue. As the trait is autosomal so there is no sex biasness. Males and females both are affected equally.

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