tructions INFECTIOUS DISEASE CASE STUDY 24 During World War 1, soldiers injured
ID: 253893 • Letter: T
Question
tructions INFECTIOUS DISEASE CASE STUDY 24 During World War 1, soldiers injured in battle often died of then-untreatable Clostridium infections. Initial infection was usually Staphylococcus or Streptococcus. Since antibiotic therapy was not available, these initial infections might be successfully treated topically only to be replaced by one of the Clostridium organisms, usually with fatal outcomes. (A) In the first, symptoms usually occur within ten days, Initial symptoms are restlessness, iitability and muscular stiffness in the jaw, neck, or limbs. Muscle spasms increase, leading to clenched jaws, and stiff and arched (hyperextended) back and neck (B) The second can develop rapidly, especially in poorly-oxygenated tissues. Typically, pain intensifies. The affected are blackens and begins to atrophy. The necrosis (death of soft tissue or bone) spreads from the site. The wound often produces and pungent gaseous odor. Systemic effects include high fever, delirium, and shock Laboratory Diagnosis Laboratory analysis of the affected tissue often yields such a variety of microbes that a definitive isolation of the causative agent is difficult to impossible. However, when isolation is successful, the first (A) is seen as a thin Gram positive bacillus with round terminal (at the end of the cell) endospore. It produces a thin spreading veil of growth over a blood agar plate, incubated anaerobically, indicating mobility The second (B) is a large, gram positive, nonmotile, encapsulated bacillus. Spores are rarely seen in culture. The colonies develop rapidly and are characterized by both complete and incomplete hemolysis of blood agar in anaerobic incubation (Extra note: This microbe has a generation time as short as 7 minutes)Explanation / Answer
Answer is A ,C and D.
They both are anaerobes and thrive in poorly oxygenated tissues. They both are the members of skin microflora and they both skin or paewnteral route as portal of entry.
Second option (they both arre commonly found in soil) is incorrect
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