Many diuretic drugs used clinically inhibit Na + reabsorption in the loop of Hen

Question

Many diuretic drugs used clinically inhibit Na+reabsorption in the loop of Henie. Predict the effect ofthese drugs on urinary excretion of Cl- andK+ . Explain

-I know that since the majority of diuretics inhibit Na+transport in the ascending limb of the loop of Henie there will beincreased concentration of Na+ excreted. Aldosterone secretion must then be triggered by the decrease ofNa+ reabsorption which then causes an increase inNa+ reabsorption and K+ secretion into thedistal tubule and cortical collecting duct and therefor an increasein K+ excretion. And as far as Cl- goesi assume it follows the Na+ . So I beleive urinaryexretion of Cl- and K+ is increased bydiuretics, atleast diurtetics other than the "potassium sparing"diuretics.

I would like to know if my reasoning is correct and if aldosteroneis indeed the major cause of excessive K+ loss.Thanks

Explanation / Answer

Your statement is correct about Na+ andCl- . The K+ excretion is due totwo reasons: 1. aldosterone action on Na+ excretion 2. A diet rich in Na+ .This is because if the dietlacks Na+ then there is no excretion ofK+. Otherwise your reasoning is correct. hope this helps.

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