7. Which of the following is not a destination for vesicles leaving the Golgi ap

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7. Which of the following is not a destination for vesicles leaving the Golgi apparatus? a. The plasma membrane b. The exterior of the cell c. Lysosomes d. Mitochondria 8. GPl-anchored proteins are synthesized a. on free ribosomes and attached to the GPI group on the outside of the ER. b. as transmembrane proteins, cleaved, and attached to the GPI group on the cytosolic surface of the ER. c. as transmembrane proteins, cleaved, and attached to the GPI group on the lumenal surface of the ER. d. on free ribosomes and attached to the GPI group on the cytosolic surface of the ER 9. The unfolded protein response involves a. general inhibition of protein synthesis b. increased synthesis of chaperones. c. increased activity of proteosomes. d. All of the above 10. Which of the following proteins do not pass through the Golgi apparatus? a. Lysosomal enzymes b. Cell surface proteins c. Ribosomal proteins d. Proteins secreted by exocytosis 11. Which of the following classes of lipids is synthesized in the a. Phospholipids b. Glycolipids c. Cholesterol d. Ceramide 12. Brain tissue is useful for studies of vesicular transport a. many brain diseases involve mutant vesicular transoort b. synaptic ve for biochemical analysis. sicles are abundant in the brain and can be isolated in la rge quantities c. the mechanisms of vesicle transport and fusion d. All of the above and fusion are unique to neurons. 13. Lysosomes digest a. proteins. b. nucleic acid. c. carbohydrates. d. All of the above 14. The pH inside lysosomes is about a. 7.0 b. 6.0 c. 5.0 d. 4.0

Explanation / Answer

Answers:

14. C, pH of lysosomes is slightly acidic between 4.5 to 5

13. D, Lysosome digest macromolecules such as nucleic acids, proteins, and polysaccharides

12. D, all of the above

11. B, golgi aparatus involves in lipid biosynthesis of class glycolipids and sphingomyelin.

10. C, ribosomal protein

9. D, ubiquitin-proteasome pathway, production of molecular chaperones and inhibition of protein synthesis all of the are involved in unfolded response of protein

8. B, GPI assembly usually occur at the cytoplasmic leaflet of the ER

7. D, mitochondria has their own protein synthesis machineries. Therefore protein sorted from lysosomes does not goes to mitochondria. additionally, only after post-translation modification cytosolic protein desteined to mitochondria.

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